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pentobarbital will enhance the stage or impact of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of ivosidenib with strong CYP3A4 inducers decreased ivosidenib plasma concentrations.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​â